Mar 2014

Altered Metal Metabolism in Niemann Pick Type C Disease

We recently collaborated with Ashley Bush’s team at the Metals Oxidation Laboratry at Florey Neurosciences to examine metal metabolism in NPC with the aim of opening up new pathways of treatment in this neurovisceral disorder. Undertaken by post-doctoral scientist Dr Ya Hui Hung and looking at both animal and human samples, we showed that metal homeostasis is disrupted in NPC, particularly zinc metabolism, and that currently available treatments do not correct this.
This suggests that new avenues of add-on treatments may be feasible, and this is being progressed into animal trials of new compounds. The study can be found
here.
ALTERED METAL METABOLISM IN NIEMANN-PICK TYPE C DISEASE

Neuropsychiatry of Movement Disorders

The unit’s 2013 Neuroimaging Fellow, Dr Brad Hayhow, has published an illustrated summary of how typical movement disorders associated with chorea, dystonia and ataxia are associated with neuropsychiatric illness. This review paper has been published in the new Columbia University movement disorders journal, Tremor.
The paper can be viewed in full here, and contains high-quality illustrations about frontal-subcortical circuits whose disruption can lead to psychiatric illness. One of the images can be found below.

NEUROPSYCHIATRY OF MOVEMENT DISORDERS
Pasted Graphic
Prototypical frontostriatal circuit.