Brain Changes in Adult NPC

Utilising methodology developed by Professor David Reutens, now at the Queensland Brian Institute, Dr Amanda Wood, from the University of Birmingham, and Drs Larry Abel and Elizabeth Bowman from the University of Melbourne’s Department of Optometry and Vision Sciences, we followed up our landmark MRI study in adults with Niemann-Pick disease type C (NPC) with a shape analysis of the corpus callosum (CC), the brain’s largest white matter fibre bundle, which connects the brain’s two hemispheres. This study demonstrated that the CC in NPC is globally thinned, but disproportionately thinned in regions similar to those seen in established schizophrenia, and may go some way to explaining the increased rate of psychosis in adults with NPC.

This paper can be found here.
Walterfang et al. Size and shape of the corpus callosum in adult Niemann-Pick type C reflects state and trait illness variables. American Journal of Neuroradiology 32: 1340-1346, 2011.